Tight Glycemic Control: Critical Care’s Balancing Act

Over a decade ago, the New England Journal of Medicine published a study identifying tight glycemic control in the intensive care unit as a critical step to improving patient outcomes. Today, a small pack of companies is trying to finally deliver on the promise.

Late night talk host David Letterman might have made the Top 10 List famous, but the New England Journal of Medicine publishes a noteworthy top 10 list of its own that identifies the most frequently cited articles in the journal’s history. At number five sits a 2001 article entitled “Intensive Insulin Therapy in Critically Ill Patients,” which makes a compelling case for adding the management of blood glucose levels in critical care patients to the list of mandatory care.

Lead author Greet Van den Berghe, MD, PhD, (then head of the department of intensive care medicine at the hospital...

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