Scrip - Pharma News And Expert Analysis For Commercial Decision Makers since 1972


Spotlight on Scrip Perspectives 24/25


Trends To Track In India: Deals, Big Pharma GCC Strategy And CAR-Ts In Motion

From continuing consolidation on the home market, big pharma appetite to double down on capability centers and notable R&D advances including traction by a second CAR-T cell therapy, the Indian market looks set for an eventful 2025. Scrip spoke to a cross-section of experts to encapsulate some of the key trends in the first instalment of this two-part roundup.




Focus On Asia


Trends To Track In India: Deals, Big Pharma GCC Strategy And CAR-Ts In Motion

From continuing consolidation on the home market, big pharma appetite to double down on capability centers and notable R&D advances including traction by a second CAR-T cell therapy, the Indian market looks set for an eventful 2025. Scrip spoke to a cross-section of experts to encapsulate some of the key trends in the first instalment of this two-part roundup.

Data Analysis


R&D


High-Dose Semaglutide Data A Mixed Bag For Novo Nordisk

 
• By 

Semaglutide 7.2mg bests placebo for weight loss at 72 weeks, but with efficacy lower than seen with Novo Nordisk’s CagriSema or Lilly’s Zepbound.

Boehringer’s Three Shots At Schizophrenia Miss The Target

 

Three parallel Phase III studies of iclepertin aiming to improve cognitive function have failed but optimism about other schizophrenia treatments is growing.

Acepodia Plays Dual-Payload Ace To Join Global ADC Race

 

Acepodia’s dual-payload antibody-drug conjugates can link multiple tumor-killing agents without antibody modification. Apart from a GPC3-targeting candidate, the Taiwan-US biotech is also working on a bispecific antibody ADC with two different payloads, its CEO tells Scrip in an interview.

Avidity Set To File First Of Three Muscular Dystrophy Drugs In 2025

 

The company is moving quickly to bring its antibody oligonucleotide conjugates to patients in three separate muscular dystrophy diseases, causing unease for its rivals.

Business


Semaglutide In 2027 Medicare Price Negotiations; Most Other Drugs Lose Exclusivity By Then

 
• By 

Novo took the biggest stock price hit of all the drug makers with products subject to Medicare price negotiations in 2027 under the IRA, but at least 11 of its peers on the list will be subject to generic competition between 2025 and 2027.

Atara In Disarray As Shares Sink On Ebvallo CRL

 
• By 

The Pierre Fabre-partnered allogeneic T-cell immunotherapy is already available in Europe but hopes of a US approval have been hit by a complete response letter citing problems at a third-party manufacturing facility.

Trends To Track In India: Deals, Big Pharma GCC Strategy And CAR-Ts In Motion

 

From continuing consolidation on the home market, big pharma appetite to double down on capability centers and notable R&D advances including traction by a second CAR-T cell therapy, the Indian market looks set for an eventful 2025. Scrip spoke to a cross-section of experts to encapsulate some of the key trends in the first instalment of this two-part roundup.

Sangamo Nearing Fabry Gene Therapy Deal To Fund Its Pipeline

 
• By 

Low on cash when Pfizer handed back rights to its hemophilia A gene therapy, Sangamo is talking to partners for its Fabry disease gene therapy to fund its two lead programs through proof-of-concept.

Scrip Originals


Asia Deal Watch: Regenxbio Licenses Two MPS Gene Therapies To Nippon Shinyaku

 

Plus deals involving Simcere/AbbVie, Daiichi Sankyo/Glycotope, Telix/ImaginAb, Harbour/Kelun/Windward, Insilico/Menarini, Samsung Bioepis/Teva, HealZen/J&J, Zai Lab/Vertex, Zai Lab/MediLink and Primrose/Serum Institute of India.

Executives On The Move: Five CMOs, 14 CEOs And 23 CFOs Among This Week’s Changes

Latest updates include changes at the top at Neuphoria Therapeutics, plus new CEOs at Cyclacel Pharmaceuticals and Norgine, among others.

Deal Watch: Bausch Companies Set Hectic Pace At J.P. Morgan With Five Deals

 
• By 

Plus deals involving Lantheus/Life Molecular Imaging, Teva/Klinge/Formycon, X4/Norgine, Biohaven/Merus, Lilly/Mediar and more.

Pipeline Watch: Six Approvals And Eight Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.