Alimentary/Metabolic


More Rivalry With Ionis In A Potentially ‘Transformational’ Year For Arrowhead

 

The company hopes to prove its RNAi platform is the most versatile and potent in cardiometabolic therapies in 2026 – and win one over on its long-standing rival, Ionis.

Scrip Asks... What Does 2026 Hold For Biopharma? Part 4: R&D Innovation

 

Enthusiastic predictions from industry leaders for ongoing progress in obesity, oncology, immunology, neuroscience and more were supported by optimism for the potential of AI and other technological advances to enable breakthroughs in processes as well as pipelines.

In Latest Blow To Novo, Hims & Hers Launches Compounded Wegovy Pill

 

Novo Nordisk said it will take legal action against mass compounding of the new oral semaglutide formulation by Hims & Hers.

The Hunt For A Monthly Obesity Drug Is Heating Up

 

Monthly obesity therapies may not have to rival the efficacy of weekly injections if they can be more convenient and help patients stay on treatment longer.

Anti-infective


Scrip Asks... What Does 2026 Hold For Biopharma? Part 4: R&D Innovation

 

Enthusiastic predictions from industry leaders for ongoing progress in obesity, oncology, immunology, neuroscience and more were supported by optimism for the potential of AI and other technological advances to enable breakthroughs in processes as well as pipelines.

perspectives 2026

Will Chinese Firms Take More Domestically Approved FIC Drugs To The World In 2026?

 

While a record number of China-originated first-in-class drugs were approved domestically in 2025, only one has so far entered clinical development overseas with its originator as the sole sponsor. But more progress is expected this year.

Valneva Scraps Ixchiq US Push Amid Safety Woes

 

Valneva's withdrawal of its chikungunya vaccine leaves Bavarian Nordic as the only remaining firm producing a shot for the condition in the US.

Novavax’s Adjuvant Licensing Strategy Continues With Pfizer Pact

 
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Novavax will get $30m up front for a non-exclusive license for its Matrix-M adjuvant, but the deal could bring in billions long-term. The biotech is negotiating similar deals with multiple firms.

Anticancer


Gilead’s Dietmar Berger Reflects On Pipeline After First Year As CMO

 
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Scrip spoke with CMO Dietmar Berger about his views on diversifying Gilead’s virology, oncology and immunology R&D efforts through both in-house research and external innovation.

Scrip Asks... What Does 2026 Hold For Biopharma? Part 4: R&D Innovation

 

Enthusiastic predictions from industry leaders for ongoing progress in obesity, oncology, immunology, neuroscience and more were supported by optimism for the potential of AI and other technological advances to enable breakthroughs in processes as well as pipelines.

Eisai Picks Up Henlius’s Serplulimab For Japan In $400m Deal

 
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Henlius planning Japanese NDA by end of March 2027 for ES-SCLC and development in several other indications.

Lilly Takes Incretins Beyond Metabolic Diseases Amid Broader Development Push

 

The drugmaker highlighted a wide array of development programs in its fourth quarter earnings, including moving tirzepatide into multiple inflammatory conditions.

Antiparasitic


Novartis Secures Approval For First Malaria Therapy for Babies

 
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Coartem Baby to be rolled out in eight African countries in the autumn.

Novartis Measures Malaria Success On Impact Rather Than Money

 
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The Swiss major’s global health chief Lutz Hegemann tells Scrip on a trip to Rwanda that being a profitable enterprise while helping to improve access to new and older therapies for those who need it most is the real measure of a successful business.

Tarsus Demonstrates Lotilaner’s Potential In Preventing Lyme Disease

 
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Lotilaner, the active ingredient in Tarsus’s Demodex blepharitis drug Xdemvy, showed significant ability to kill ticks in a small Phase IIa study. Analysts call the Lyme program a likely out-licensing opportunity for Tarsus.

Serum-Biocon Deal Sees COVID Reality Tweak Even As Oxford’s Malaria Vaccine Holds Promise

 
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Gains from its COVID-19 vaccine made Serum Institute’s founder the world’s richest healthcare billionaire. But the demand for boosters hasn’t materialized as expected, leading to a deal with Biocon being tweaked. Meanwhile, gains from India’s first indigenously-developed HPV vaccine and Oxford-partnered malaria vaccine seem imminent.

Blood and Clotting


In Case You Missed It: Trial Updates, FDA Approvals & Rejections

 

Catch up on the developments released in the last days of 2025, from year-end FDA approvals, complete response letters and several trial disappointments.

Gamida Cell Goes From Strength To Strength With Another US FDA Nod

 
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The company, which was on the verge of bankruptcy last year, has secured an expanded approval for Omisirge for severe aplastic anemia.

ASH: Novartis’s Ianalumab Has Disease-Modifying Potential In ITP

 
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Novartis presented Phase III results for anti-BAFF/ADCC antibody ianalumab in the second-line treatment of immune thrombocytopenia but will wait for first-line data to file for approvals in 2027.

ASH: Beam Can Rival Vertex In Sickle Cell But Bulsufan Deaths Cast A Shadow

 

The base-editing company’s risto-cel may have an efficacy edge over Vertex’s Casgevy, but both will be held back by safety concerns about chemotherapy preconditioning for patients.

Cardiovascular


More Rivalry With Ionis In A Potentially ‘Transformational’ Year For Arrowhead

 

The company hopes to prove its RNAi platform is the most versatile and potent in cardiometabolic therapies in 2026 – and win one over on its long-standing rival, Ionis.

Bayer Buoyant As Asundexian Shows 26% Reduction In Stroke

 
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The co-principal investigator of OCEANIC-STROKE tells Scrip that the oral Factor XIa inhibitor could be paradigm-changing.

Novartis Gets Two New Blockbusters In Scemblix And Leqvio

 
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The blood cancer drug and the cholesterol lowerer will be major growth drivers through to 2020 and beyond.

New Epidarex $145m Fund Is A Fillip For UK Biotech

 
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Fund IV exclusively targets company creation and early-stage investing across the UK and the US.