Heart Failure: Next-Gen VADs Fuel Optimism Amid Challenges

Heart failure (HF) remains one of the most challenging and costly health problems today, affecting more than 20 million patients worldwide, and causing more than seven million deaths per year. In the US alone, the number of people with HF is projected to increase from five million in 2012 to eight million in 2030, according to the American Heart Association (AHA), driven by an aging population and increasing prevalence of conditions that contribute to this degenerative, progressive disease, including ischemic heart disease, hypertension, and diabetes. HF has become a major burden on health care systems and its economic impact is staggering. The annual direct and indirect costs of HF are projected to more than double over the next 20 years, increasing from $31 billion to $70 billion, according to 2014 AHA estimates. Much of that cost is due to the frequent hospitalizations typical of HF patients, who seek symptomatic relief from cardiorenal syndrome, a debilitating condition that causes fluid retention and shortness of breath. In fact, HF is the leading cause of hospitalization in patients over 65 years of age in the US, and preventing re-hospitalization of these patients has become a primary goal of hospitals, particularly since the Centers for Medicare and Medicaid Services (CMS) began financially penalizing hospitals with excess HF admissions. (See Also see "Heart Failure Devices: Raising Roadblocks To Readmission" - Medtech Insight, 27 January, 2012..)

Given the enormity of this problem, there is an urgent need to find innovative ways to treat HF earlier in...