Phase II development of lead phosphodiesterase-4 inhibitor compound for asthma, COPD discontinued, company announces April 25. Merck, which was developing a once-daily oral formulation under a collaborative agreement with Celltech, says it continues to study other PDE-4 inhibitor molecules for asthma and COPD, although "the timing for the development of these other molecules is not certain." Merck has demonstrated success with backup compounds where initial lead agents have failed in clinical trials - Singulair was a successor product to Venzair, Merck's first leukotrine antagonist asthma candidate whose development was halted due to clinical toxicity...
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Advanz Pharma would have had to show that the European Commission’s decision to revoke Ocaliva’s conditional marketing approval risked causing serious and irreparable harm, according to lawyers from Van Bael & Bellis.
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A new pilot aims to take Brazil closer to ‘digital transformation.’
Recent and upcoming US FDA advisory committee meetings and a summary of the topics covered.
The UK’s research-based pharma industry and medical research charities have set out clear action points to drive greater diversity and inclusion in clinical trials.
Blenrep, GSK’s multiple myeloma therapy, faced a major setback when it was withdrawn from the market in 2022. The drug has since made a return as a second-line therapy, and is on track to being reimbursed in England.
