Right Dosing, Scheduling Key To Anticipating Resistance, Creating Synergistic Combos In Drug Development

The art of developing synergistic combinations of novel drugs that can win the race against resistance mutations was much discussed at the American Association for Cancer Research meeting in Chicago March 31 - April 4.

Drug makers who aim to co-develop two drugs in therapeutic combinations face a burden of putting together more than twice the preclinical data needed to pave a single drug’s way to the clinic because of the complexity of dosing the two drugs effectively, panelists agreed at the American Association for Cancer Research April 3.

The panel on co-development of investigational drugs was part of a new Regulatory Science and Policy Track added to the...

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