Split Tablet Stability Testing Leaves Advisory Panel Uniformly Puzzled

FDA wants manufacturers to demonstrate split tablets are safe under ideal conditions, but advisory committee members wonder how useful patients will find the data.

Requiring manufacturers to demonstrate the stability of their scored tablets after 90 days seemed logical, but advisory committee members appeared to question the usefulness of the data for patients.

FDA wants the study to show under essentially ideal conditions – 25 degrees Celsius and 60% relative humidity – that the split tablets remain stable.

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