Out Of The Ashes: Roche’s Dalcetrapib Data Suggest Still Hope For CETP Inhibitor Class

Experts see various reasons why Roche’s HDL-raising drug may have failed to demonstrate benefit in the dal-OUTCOMES study, including insufficient potency resulting from only partial CETP inhibition. Final word on the class’ fate likely will not be written until outcomes studies by Merck and Lilly report out in several years.

The final word on the efficacy and safety of the CETP inhibitor class will await results from ongoing studies by Merck & Co. Inc. and Eli Lilly & Co. now that published data from Roche’s failed trial of dalcetrapib suggest there still could be hope for this class of HDL cholesterol-raising drugs.

Roche announced the termination of dalcetrapib’s development in May after an independent data safety and monitoring board advised discontinuation of the 15,800-patient dal-OUTCOMES study due to a lack of clinically meaningful efficacy Also see "

More from Archive

More from Pink Sheet