Minimal Residual Disease Endpoint Would Aid Leukemia Drug Development, Experts Say

An international panel of hematology experts tells an FDA/ASCO workshop Feb. 27 that minimal residual disease would be a useful surrogate endpoint for assessing the effects of chronic lymphocytic leukemia therapies because it has been strongly correlated with longer-term outcomes in the disease.

Qualifying minimal residual disease as a response biomarker that can be used as a regulatory surrogate endpoint would facilitate the development of new drugs for chronic lymphocytic leukemia, experts have advised FDA.

During a Feb. 27 public workshop on minimal residual disease (MRD) as a surrogate endpoint in CLL, an international panel...

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