Sanofi Oncology’s Transformation Rests On Fedratinib, At Least In The Near-Term

The JAK2 inhibitor for myelofibrosis is the company’s most advanced oncology candidate and will be an anchor for Sanofi as it looks to build a portfolio of next-generation cancer drugs after the late-stage failure of the PARP inhibitor iniparib.

After halting development of the Phase III breast and lung cancer treatment iniparib in June because of lack of efficacy, Sanofi is pinning its near-term oncology hopes on fedratinib, a JAK2 inhibitor for myelofibrosis and the sole remaining oncology asset in Phase III.

Fedratinib could represent an important turning point for Sanofi’s oncology portfolio, which is largely made up of mature

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