Large Simple Trials Need FDA Boost, IoM Report Says

“Clear specific guidance” from the agency would help close the perception gap between what types of data industry thinks FDA wants and what the agency actually expects, according to a summary of a 2012 Institute of Medicine workshop.

FDA guidance on use of large simple trials would help encourage conduct of such studies in lieu of longer, more complex and costly randomized controlled trials, according to a recently released Institute of Medicine report.

Such guidance could help reduce the fear – which FDA asserts to be unfounded – among biopharmaceutical sponsors that the agency will request additional clinical data points beyond those generated...

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