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Busy Days For Hep B Drug Development

Activity in the hepatitis B field is heating up, as evidenced by recent announcements from J&J, Gilead and Dynavax.

Johnson & Johnson isn't the only biopharma looking to make gains in the treatment of hepatitis B, which is addressed currently with existing nucleotide analogue therapies such as Viread (tenofovir disoproxil fumarate). Gilead Sciences Inc. has been advancing a new formulation of tenofovir for both HIV and HBV, and filed tenofovir alafenamide (TAF) for approval as a once-daily, 25 mg treatment for chronic HBV at FDA on Jan. 12.

TAF is a prodrug of the maturing Viread, and is part of one already-filed combination therapy candidate for HIV, as well as two other planned filings ([A#14160105004]). Through its...

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