Genzyme’s Asian Expertise Drives Alnylam Co-Development Pact For TTR Candidates

RNAi pioneer Alnylam is partnering its transthyretin-mediated amyloidosis program with Genzyme in Japan and Asia-Pacific, while planning to keep rest-of-world rights to the program in-house.

Two of U.S. biotechnology’s best-known names – rare-disease specialist Genzyme Corp., which Sanofi bought last year, and RNA-interference pioneer Alnylam Pharmaceuticals Inc. – are teaming up in an agreement announced Oct. 22 to co-develop and commercialize RNAi therapeutics for transthyretin-mediated amyloidosis (ATTR) disorders in Japan and Asia-Pacific. Alnylam gets $22.5 million upfront under the deal, along with the potential for up to $50 million in milestones and mid-teen to mid-20s% royalties on product sales.

The tie-up centers on ALN-TTR02, a Phase II RNAi therapeutic discovered and developed by Alnylam, along with ALN-TTRsc, a preclinical...

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