FDA Exploring Limited-Use Approvals For Antibiotics Based On Small Development Programs

The agency would like to have a “special medical use” category for drugs, such as antibiotics for bacteria resistant to current therapies, that could be approved based on small trials and whose labeling says they should not be prescribed off-label.

FDA would like to have a new “special medical use” category for drugs that could be approved based on a small clinical development program and that would have a limited indication for specific populations.

The impetus for, and initial focus of, the program would be antibiotics for drug resistant bacteria, Commissioner Margaret Hamburg and Center for Drug Evaluation and Research Director Janet Woodcock told...

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