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GlycoMimetics’ Sickle Cell Candidate Nearly Ready For Hand-Over To Pfizer

Biotech focused on role of carbohydrates in biological processes completes Phase II program of lead candidate for sickle cell disease. Under a 2011 partnership, Pfizer takes over development of GMI-1070 in Phase III.

GlycoMimetics Inc. unveiled promising Phase II data for GMI-1070, its pan-selectin inhibitor for sickle cell disease, on April 15. Partnered since 2011 with Pfizer Inc., the compound offers the potential for the first drug therapy to treat vaso-occlusive crisis episodes in patients with sickle cell disease, a genetic disorder that affects more than 80,000 Americans.

In the double-blind, placebo-controlled Phase II study, the Gaithersburg, Md., biotech found that ‘1070 reduced duration of vaso-occlusive crisis (VOC),...

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