‘Low-T’ Drugs Need Randomized CV Safety Trials, FDA Panel Says

Advisory committees also vote to change indication of testosterone replacement therapies, saying new trials are needed if sponsors want to win the old claims back.

Sponsors of testosterone replacement therapies should be required to conduct randomized controlled trials to further assess a potential cardiovascular risk, FDA advisors said Sept. 17.

Safety and efficacy trials should also be conducted if companies want to claim an indication for age-related hypogonadism conventionally known as “Low-T,” the majority of the joint panel of FDA’s Bone, Reproductive and Urologic Drugs

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