Regulus' MicroRNA Approach May Hold Key To 4-Week HCV Cure

RG-101 tested in combination with Gilead's Harvoni and two other direct-acting antivirals approved for hepatitis C shows the ability to cure chronic HCV infections with a four-week therapeutic regimen.

Top-line data from a Phase II study combining Regulus Therapeutics Inc.'s RG-101 with approved direct-acting antiviral drugs for hepatitis C indicate that adding a microRNA therapeutic to a DAA – particularly Gilead Sciences Inc.'s Harvoni – may finally bring the concept of four-week curative treatment for HCV to reality.

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