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Gilead's Epclusa Approved As First Pan-Genotypic HCV Therapy

Fixed-dose combo of sofosbuvir and velpatasvir is approved to treat genotypes 1-6 and be the first ribavirin-free regimen for genotypes 2 and 3 of the virus.

The momentum in hepatitis C continues for Gilead Sciences Inc. as its latest single-tablet, fixed-dose combination regimen, named Epclusa, obtained FDA approval June 28. The combination of the novel pan-genotypic NS5A inhibitor velpatasvir with the previously approved sofosbuvir becomes the first pan-genotypic HCV regimen approved, as well as the first single-tablet regimen for patients with genotypes 2 or 3 of the virus.

Epclusa is approved for 12 weeks of therapy for patients with genotypes 1-6 of HCV, including patients with moderate or...

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