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Galectin Hopes To Set Surrogate Endpoints For NASH Cirrhosis, Despite Trial Failure

 
• By Joseph Haas

Failure of small NASH cirrhosis study does not present much read-through to the larger class of NASH drugs in development. Galectin hopes its ongoing Phase IIb trial will validate its galectin-3 inhibitor in a more advanced disease state than most NASH candidates are pursuing.

Liver

Despite the failure in a small Phase IIa trial, Galectin Therapeutics Inc. is hoping both that a larger ongoing trial testing its NASH candidate GR-MD-02 in NASH cirrhosis is better designed to succeed and that it can validate some non-invasive measures of liver stiffness to serve as a much-needed surrogate endpoint in nonalcoholic steatohepatitis.

The Norcross, Ga., company reported after market closing on Sept. 27 that GR-MD-02, a carbohydrate-based galectin-3 inhibitor, missed the primary...

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