Accelerated Approval Should Be Less 'Wide Open,' Califf Says

FDA should write more about its interpretation of regs and apply it more consistently across divisions, commissioner says.

FDA's standards for applying accelerated approval should not be "totally wide open," but also should not set a bright line for access to the expedited approval pathway, Commissioner Robert Califf said.

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Another Regeneron CRL Prompts Regulatory Operations Questions

 

CEO Len Schleifer said during the company’s first quarter earnings call that most of the complete response letters the company has received related to third-party suppliers, not efficacy or safety.

New EU Filings

 

Plozasiran, Arrowhead Pharmaceuticals' treatment for familial chylomicronemia syndrome, is among the latest products that have been filed for review by the European Medicines Agency for potential EU marketing approval.

US FDA Commissioner Rejected Some Proposed Reorg Plans

 
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FDA Commissioner Martin Makary said in an interview that he will use the current structure to reform the agency. He also plans to address employee morale.