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For Recombinants To Approach mRNA Speed, US FDA Urged To Select Monovalent COVID Boosters

 
• By Bowman Cox

US FDA and BARDA ask makers of recombinant protein SARS-CoV-2 vaccines how they could match mRNA vaccines in post-strain-selection turnaround time for annual booster doses. The reply: give them a fighting chance by selecting just one strain instead of two.

vaccine rockets
how recombinant boosters could keep up • Source: Shutterstock

If the US government wants slower options in the COVID-19 vaccine race to play a role with annual boosters now that mRNA vaccines have raised the bar on speed to market, then it should plan on boosting with monovalent vaccines rather than bivalent, several sponsors and independent experts told a 27 April workshop.

There is no downside to such a strategy, they said, because monovalent COVID-19 vaccines are quicker to manufacture and work as well or better than bivalent alternatives.

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