‘We Can’t Go Back In Time’: CIR Panel Grapples With Prostaglandins Review Without Animal Test Data

11 Dec 2023

• By Lauren Nardella

In its safety assessment of two prostaglandin analogues, the Expert Panel for Cosmetic Ingredient Safety determined that certain read-across data from potentially related ingredients were not enough to extrapolate and apply to a prostaglandin review. This and more from the panel's 4-5 December meeting.

Animal testing of cosmetic ingredients has been almost completely eliminated globally, but validated, regulatory-accepted alternative methods continue to be lacking for certain endpoints, presenting challenges that were brought into relief at the 4-5 December meeting of Cosmetic Ingredient Review experts.

CIR’s Expert Panel for Cosmetic Ingredient Safety was tasked at the meeting with reviewing ethyl tafluprostamide (ET) and isopropyl cloprostenate...