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Orteronel Leaves Hole In Millennium/Takeda Pipeline

The non-steroidal androgen synthesis inhibitor failed to show a survival benefit in chemotherapy-naïve prostate cancer patients after also failing in post-chemo patients in 2013. With Takeda ending development of the Phase III candidate, its Millennium cancer pipeline is reduced to a pair of Phase III candidates.

The loss of prostate cancer candidate orteronel reduces by one-third the Phase III pipeline at Takeda Pharmaceutical Co. Ltd.’s oncology affiliate, Takeda Oncology

The product had become a longshot anyway, but with orteronel failing to demonstrate an overall survival benefit in the pre-chemotherapy setting in metastatic castration-resistant prostate cancer, Takeda announced June 19...

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