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Sangamo BioSciences Inc.

 
• By Myrna Watanabe

Drug Discovery; Molecular Diagnostics. Sangamo BioSciences' zinc finger DNA-binding proteins can be rationally designed to bind to any DNA sequence, and may have several commercially useful applications; production of human therapeutics, functional genomics and gene diagnostics.

Suppose you could just point a finger at a gene you wanted to turn on or turn off. That's basically what Sangamo BioSciences Inc. has shown they can do with their engineered zinc finger proteins that can be rationally designed to bind to any DNA sequence. The company calls the platform technology Uniform Gene Recognition (UGR) and is developing it into three broad commercial categories: Universal Gene Regulation for producing human therapeutics, Universal GeneTools for use in functional genomics research, and Universal Gene Identification for gene diagnostics.

Zinc finger DNA-binding proteins are transcription factors that recognize specific DNA base pair sequences based upon a set of "recognition rules." These binding proteins were originally discovered in 1985 in...

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Final Chance To Have Your Say: Take Scrip's Reader Survey This Week

 
• By Eleanor Malone

Editor’s note: This is your final call to participate in the survey to better understand our subscribers’ content and delivery needs. The deadline is 20 September.

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• By Andrew McConaghie

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• By Anabel Costa-Ferreira

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• By Sushmita Panda

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• By Joseph Haas

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