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Rational Therapeutics

 
• By Wendy Diller

Diagnostics & Drug Development; Cancer. Rational Therapeutics' ex vivo apoptotic assay,which measures cell death in culture, will help select appropriate drugs for individual cancer patients and aid in the cancer drug discovery process. The assay measures the ability of drugs, radiation, biological agents and combinations of all of the above, to induce cell death.

There aren't many tools which are good at reliably determining the effectiveness of cancer drugs. Immortalized cell lines have long been used because they are consistent and readily available, but they aren't good mimics of the human condition. Human tissue would seem to be a better choice but samples are difficult to obtain and maintain.

The National Institutes of Health undertook an ambitious program to develop human tumor cell lines for screening years ago....

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