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Peptimmune Inc.

 
• By Mary Stuart

By intervening at the level of antigen processing and presentation, Peptimmune aims to develop drugs that downregulate the inappropriate immune response that occurs in such autoimmune disorders as multiple sclerosis and rheumatoid arthritis and to boost the response in the case of HIV and other viruses.

The goal of several companies working in autoimmune diseases is to selectively suppress disease-causing T-cells, thereby interrupting the complex cascade of immunological reactions very early in the process, before damaging inflammatory events occur. These development efforts are attempting to intervene upstream of the junctures at which the currently available drugs interact, or, "at the headwaters of the immune system," according to Peptimmune Inc. 's president and co-founder Ben Bronstein.

By intervening at the level of antigen processing and presentation, Peptimmune aims to develop drugs that downregulate the inappropriate immune...

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Final Chance To Have Your Say: Take Scrip's Reader Survey This Week

 
• By Eleanor Malone

Editor’s note: This is your final call to participate in the survey to better understand our subscribers’ content and delivery needs. The deadline is 20 September.

Shape Our Content: Take The Reader Survey

 
• By Eleanor Malone

Editor’s note: We are conducting a survey to better understand our subscribers’ content and delivery needs. If there are any changes you’d like to see in the coverage topics, content format or the method in which you receive and access Scrip, or if you love it how it is, now is the time to have your voice heard.

Galapagos Expands Point-Of-Care CAR-T Study To The US

 
• By Andrew McConaghie

CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.

Analysts Split On Eisai’s Chances Of Changing EU Regulator’s Mind On Leqembi

 
• By Andrew McConaghie

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China Signals Restarting IPOs For Unprofitable Biotechs

 
• By Dexter Jie Yan

The China Securities Regulatory Commission has proposed a new “growth tier” for the STAR Market of the Shanghai Stock Exchange, to reinstate the market’s listing standards for unprofitable firms.

BIO Notebook: Woodcock Calls For Doing The Right Thing, Dealmaking Remains Constrained

 
• By Mandy Jackson, Joseph Haas, and Sarah Karlin-Smith

Highlights from Day Four of the BIO International Convention include Woodcock offering practical advice on rare disease trials, the sorry state of dealmaking mid-year, Novartis discussing its approach to partnering, and Generate looking for funding to move into Phase III.

Syncona Looks To Go Private As Market Decline Deepens

 
• By Andrew McConaghie

While some are calling for Syncona to be wound up, the UK-based company believes many existing and new investors will back the creation of new private fund.