High-tech discovery methods so broadly embraced over the past decade haven't delivered expected gains in productivity. Phenomix Corp. thinks it will fare better by harnessing mouse models of disease, randomly mutagenizing genes, checking the resulting phenotypes for beneficial changes then tracking back to the gene.
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The company has established the efficacy of its biologic Saphenlo in systemic lupus erythematosus but is now investing across modalities to stay ahead of rivals.