Two-and-a-half years ago in START-UP, Oxford Biosciences VC Doug Fambrough, PhD, divided the companies developing next-generation sequencing technologies into five categories: those who offered incremental improvements to the sequencing process; microfluidics specialists that could make front-end sample preparation more efficient; companies relying on PCR-based sequence amplification; companies attempting to sequence by base addition with little or no amplification; and firms attempting to read sequence "in real time" as strands of DNA passed through an apparatus. (See "Making a New, Big Splash in the Sequencing Market," START-UP, May 2004, Also see "Making a New, Big Splash in the Sequencing Market" - Scrip, 1 May, 2004..)
The categories still hold up today, Fambrough says, and understandably, certain fields have made progress while others haven’t. Attempts to...
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