Treating Traumatic Brain Injury

Past failures guide start-ups that seek to develop drugs for this silent epidemic, but will investors follow?

Nearly every day American soldiers in Iraq incur combat head wounds. Whether the injury is penetrating or closed, the forward medics have no way of diagnosing the extent of the trauma to the soldiers’ brains. After evacuation, the base hospital can offer no treatments except boring a hole in their skulls to relieve swelling. The same bleak scenario holds true at the scene of a traffic accident or when a child falls on her head. Yet every year in the US at least 1.4 million people suffer traumatic brain injuries (TBIs), some 50,000 resulting in death and another 80,000 leading to long-term disabilities.

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