Vienna-based f-star Biotechnology's platform allows it to enhance the functionality of antibodies by introducing additional binding sites. F-star is also investigating antibody fragments and what it calls "compressed" antibodies, or protein scaffolds with key antibody characteristics tacked on, but much smaller in size. These, it claims, may be easier to produce than full-sized antibodies, with better tissue penetration and potentially better efficacy.
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CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.
A final rejection of Leqembi could also spell the same fate for Lilly’s rival drug but public outcry and demand for Alzheimer’s therapies might force the regulator’s hand
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