The gastrointestinal problems linked to NSAIDS are certainly no secret: the ability to mitigate them turned Vioxx into a blockbuster drug, that is, until it was pulled from the market because of cardiovascular problems. Now, Logical Therapeutics in-licensed rights to a pro-drug of naproxen that it thinks will have the GI-safety profile of Vioxx and the cardiovascular safety profile of naproxen.
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The biotech announced positive topline results from the Phase II SUMMIT study in non-advanced systemic mastocytosis, with data for advanced SM and GIST expected later this year.