Oncology drug developer Proacta Inc. is taking advantage of tumor hypoxia to activate a nontoxic prodrug to a cytotoxic chemotherapeutic. Since the agent acts only in areas of low oxygenation, it is nontoxic to normal tissues.
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CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.
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