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Alnylam, Isis JV Regulus to Tackle MicroRNA

 
• By Chris Morrison

Isis and Alnylam have entered a joint venture in microRNA technology and therapeutics called Regulus. The company's first product candidate will be a next-generation antisense therapy against miR122, a microRNA involved in hepatitis C virus replication.

Oligonucleotide drugs, high-science start-ups, top figures from academia, and early IP consolidation. Both Isis Pharmaceuticals Inc. and Alnylam Pharmaceuticals Inc. have been there before. And now they’re there together, having created Regulus Therapeutics LLC, a JV established in mid September to exploit the two firms’ IP and know-how in targeting micro RNA. [See Deal]

Micro RNAs (miRNAs) are endogenous, non-protein-encoding single-stranded RNA oligonucleotides believed to broadly regulate gene expression. Antagonizing miRNAs is a new...

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