ProtAffin Biotechnologie AG's technology is based on the interactions between pro-inflammatory proteins such as chemokines, and leucocytes and endothelial cells that drive many acute and chronic inflammatory processes such as ischemia/reperfusion injury and rheumatoid arthritis. The company's CellJammer platform uses structural bioinformatics and rational protein engineering to take a target protein agonist that naturally binds to a GAG ligand and to create an antagonist that binds with higher affinity and blocks the target protein-GAG interaction.
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CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.
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