Centrose's automated sugar synthesis platform CarboConnect can quickly and economically synthesize drugs with a wide variety of natural and unnatural sugars attached to them. The inspiration came from sugars found in natural products. Many of the antibiotics produced by microorganisms and plants contain sugars, but they are structurally different from sugars found in animal physiology. The company has already completed some proof-of-concept studies on derivative drugs in which unnatural sugars increased potency and in some cases changed the mechanism of action.
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Plus deals involving Basilea/Venatorx, CorMedix/Melinta, SERB/Y-mAbs, XOMA/Lava, XOMA/Hillevax, MaxCyte/Adicet/Anocca and Bausch Health/DURECT.
Lilly said prices governments pay in developed countries, including those in Europe, need to increase to make US drug prices lower, rebalancing costs as CEO David Ricks recently advocated.
The drug is one of multiple candidates in the class that have been pulled from development, though it is not the company’s lead candidate.
