Through the Palace Walls: Blood-Brain Barrier Transport Technologies

Delivering compounds across the blood-brain barrier remains the rate limiting step in brain-drug development, yet the problem generally gets ignored until it's too late. Several biotechs are bringing novel strategies to finding a solution, focusing especially on brain cancers. Success may open the floodgates of CNS drug development.

Marc Wortman

The blood-brain barrier gets no respect. It should. Fewer than 2% of drugs have the requisite properties to get across the BBB. That’s still better than biopharmaceuticals’ success rate. Without assistance, no large molecule drug can penetrate the brain at all—keeping many of the most promising central nervous system therapeutics from ever reaching their targets

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