In addition to camptothecins and HDAC inhibitors, Arno Therapeutics Inc.'s pipeline of cancer candidates includes a Phase I agent that targets the PI3K/Akt pathway. Arno thinks it's potentially a first-in-class compound that could have broad activity against a range of solid and liquid tumors. Furthermore, preclinical data show synergy with approved targeted agents.
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The US FDA approved Insmed’s second product, the DPP1 inhibitor Brinsupri (brensocatib) for non-cystic fibrosis bronchiectasis. The company launched the drug immediately with a list price of $88,000 per year.
Deal Snapshot: Bayer will take over development of the asset once Kumquat completes a Phase Ia clinical trial, but the biotech firm may opt in to share US profits and losses.
Madrigal and Syndax update investors on their key launches, while Merck KGaA weighs in on the possibility of direct-to-consumer sales in the US.
