Research has now revealed the mechanism underlying the anesthetic ketamine's rapid and sustained antidepressant effect: it activates an important signaling pathway in the prefrontal cortex of the brain. The findings provide clues that could lead to faster-acting drugs for depression or potentially even the adoption of current drugs for this use or augmentation of the effects of existing antidepressants.
Mark L. Ratner
A research team at Yale University has revealed the mechanism underlying ketamine's rapid and sustained antidepressant effect: the anesthetic...
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