biocrea GMBH, a 2010 management buy-out of Finland's Biotie Therapies, is developing phosphodiesterase inhibitors for diseases of the central nervous system, memory disorders and schizophrenia. Biocrea's novel approach to drug development may make it feasible to produce more specific inhibitors at the level of PDE subfamilies and/or isoforms, in order to optimize their efficacy and side-effect profiles.
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