Belgian firm PharmaNeuroBoost NV creates NCEs out of existing therapeutics combined with the company’s proprietary boosting technology. The most advanced product in its pipeline, PNB01, is a combination of a low dose of pipamperone, a selective antagonist of the 5-HT2A and dopamine-4 receptors, with a fixed dose of the SSRI citalopram. It will soon embark on a Phase III pivotal trial comparing PNB01 with standard of care for treatment of major depressive disorder.
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