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A More Integrated Approach To Looking At GPCR Signaling

G protein-coupled receptors are the most prolific initiators of cell signaling pathways. The largest class of drug targets, they are also, unfortunately, the most intractable to drug development. Three research papers shows how combining different techniques -- crystallography, hydrogen exchange, and electron microscopy -- can shed new light on the nuances of GPCR signaling and how this kind of integrated approach could help identify new drug targets.

Mark L. Ratner

Membrane-bound G protein-coupled receptors (GPCRs) are the most prolific initiators of cell signaling pathways. They help sense a wide range of signals – from hormones, neurotransmitters and nutrients to sensory...

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