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Discredited SIRT1 Stops DNA Damage In Neurons

 
• By Mark Ratner

SIRT1, the molecule activated by the controversial anti-aging supplement resveratrol, has been among the most disappointing of drug targets but now, research has linked it, along with the enzyme HDAC1, to the ability to stabilize the genome following DNA damage. The work is encouraging for the development of activators of SIRT1 and HDAC1 as neuroprotectants and DNA repair agents.

SIRT1, the molecule activated by the controversial anti-aging supplement resveratrol, has been among the most disappointing of drug targets. But now, research has linked it, along with the enzyme HDAC1, to the ability to stabilize the genome following DNA damage. The work is encouraging for the development of activators of SIRT1 and HDAC1 as neuroprotectants and DNA repair agents.

The development of small-molecule activators of SIRT1, a member of the sirtuin gene family, and a platform around sirtuin biology in general, prompted GlaxoSmithKline PLC to pay an astonishing...

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