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Full Monty On Pfizer’s Failed 5-HT6 Alzheimer’s Drug Leaves Hope For Class

 
• By Emily Hayes

Presentation of data at Alzheimer’s Association International Conference highlights failure of Pfizer’s 5HT6 antagonist PF-05212377, while still leaving room to hope for others in class like Lundbeck’s idalopirdine and Axovant’s RVT-101

Jigsaw brain

The presentation of full Phase II data for Pfizer Inc.’s failed serotonin 5-HT6 antagonist PF-05212377 at the Alzheimer’s Association International Conference is disappointing, but still leaves room for others in the class to succeed, like Lundbeck Inc.’s idalopirdine and Axovant Sciences Ltd.’s RVT-101, now dubbed intepirdine.

Antagonists against 5-HT6 are part of an emerging oral class of drugs that have shown modest efficacy in mid-stage studies for

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