Top-line data from the 510-patient Phase III SELECT-1 trial of AstraZeneca PLC's MEK 1/2 inhibitor selumetinib failed to show any benefit on the primary endpoint of progression-free survival (PFS) when used in combination with docetaxel chemotherapy for the second-line treatment of patients with KRAS mutation-positive (KRASm) locally-advanced or metastatic non-small cell lung cancer (NSCLC). There was also no sign of any benefit on overall survival (OS).
Another Late-Stage Failure For AstraZeneca's Selumetinib
AstraZeneca's novel targeted anticancer selumetinib has missed its endpoints in a Phase III study in lung cancer, the second late-stage failure for the product, which last year disappointed in uveal melanoma.
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