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Is It The End For OncoGenex? Custirsen Fails In Second Phase III Prostate Cancer Trial

 
• By Mandy Jackson

Custirsen, the lead drug candidate from OncoGenex, failed in a second Phase III clinical trial – a trial that may have represented the company's last, best hope of success.

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OncoGenex Pharmaceuticals Inc., which pinned its hopes on drug candidates that may boost the effectiveness of existing therapies, is considering its "strategic alternatives" now that its clusterin-targeting asset custirsen has failed in a second Phase III prostate cancer clinical trial.

The AFFINITY trial was the Bothell, Washington-based company's last hope of proving custirsen's value in prostate cancer after the Phase III SYNERGY failure in 2014 caused Teva Pharmaceutical Industries...

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