Lundbeck's Alzheimer's Strategy Targets Symptoms And Disease Modification

The private company may be behind the leaders, but with a long-term plan and a strategy of coming in with complementary therapies like the 5-HT6 receptor antagonist idalopirdine and the dopamine antagonist Rexulti (brexpiprazole), it could be a stable player in Alzheimer's.

Jigsaw brain

The spotlight on H. Lundbeck AS's Phase III drug idalopirdine doesn't shine quite as bright as the lights illuminating other late-stage Alzheimer's disease (AD) programs, since it treats the symptoms and not the underlying cause of AD. But the Danish company believes that even when disease-modifying treatments are available, there still will be a considerable need for symptomatic therapies.

Executive Vice President of Research and Development Anders Gersel Pedersen told Scrip that a combination of approaches are needed, so Lundbeck is working on drugs to treat Alzheimer's symptoms and other therapies that may slow the disease's progression

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