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Rigel Optimistic On Fostamatinib Despite Narrow Phase III Benefit

 
• By Joseph Haas

Rigel's SYK inhibitor fostamatinib met the primary endpoint in the first of two pivotal Phase III trials in chronic ITP, but yielded a treatment effect in only 18% of the patients. CEO Raul Rodriguez discussed the data in an interview.

Rigel Pharmaceuticals Inc. has produced positive Phase III data with the platelet drug fostamatinib in chronic/persistent immune thrombocytopenia, putting the oral spleen tyrosine kinase (SYK) inhibitor on footing for a potential approval after the company failed to successfully develop the drug in rheumatoid arthritis.

The South San Francisco, California company reported results from the first of two identical trials in Rigel's Phase III FIT clinical program on Aug. 30

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