AZ Hopes Coupling GLP-1 Bydureon and SGLT-2 Forxiga Is Paradigm Shift

 
• By Sten Stovall

AstraZeneca hopes positive results from its DURATION-8 trial combining its GLP-1 drug Bydureon and SGLT2 product Forxiga for the first time will spur use – and sales – for each, and open the way for an additional line of defense for type 2 diabetes patients before they are moved onto insulin.

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Results of AstraZeneca PLC’s late-stage study dubbed DURATION-8 is the first trial to evaluate the combination of the two diabetes treatments Bydureon (GLP-1) and Forxiga (SGLT-2) and confirmed what many experts had presumed - that they work better together than separately at reducing blood sugar in patients whose diabetes couldn’t be controlled with first-line therapy metformin, potentially opening a new treatment approach.

The study, released at this year’s annual meeting of the European Association for the Study of Diabetes (EASD)...

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