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Arrowhead Misfires: Abandons Clinical Programs, But Keeps Amgen Deal

 
• By Sukaina Virji and Emily Hayes

Arrowhead Pharmaceuticals shifts focus to subcutaneous platform after abandoning lead hepatitis B program and related products due to toxicity concerns, resolving to lay off 30% of staff.

Arrowhead Pharmaceuticals Inc. says it is shifting its focus to programs developed with its subcutaneous platform after abandoning its lead hepatitis B vaccine ARC-520 and two other related intravenous products amid regulatory concerns about toxicity.

The company announced late on Nov. 29 that it was dropping development of three clinical intravenous candidates – ARC-520, ARC-521 and ARC-AAT – and refocusing efforts on subcutaneous and extra-hepatic delivery programs

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