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Istradefylline Further Down But Still Not Quite Out In Parkinson’s?

 
• By Ian Haydock

Despite the long and troubled history of the molecule, Kyowa Hakko Kirin has persisted with the development of istradefylline for Parkinson's disease, but a new Phase III failure might be the last straw for the A2a antagonist.

Japan's Kyowa Hakko Kirin Co. Ltd. announced the start of an additional international Phase III program for its first-in-class oral adenosine A2a receptor antagonist istradefylline just over three years ago, with an eye on trying again for a long-sought US approval for use in Parkinson's disease.

Fast forward to the present and disappointing new top-line results from the placebo-controlled trial might prove to be the final nail in the coffin of the drug in this indication, at least outside Japan,

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